Reporting to senior team leader, work with a group of in vitro assay biologists, learning and coaching group members to improve skills and productivity
Independently design, conduct, optimize and proactively troubleshoot assays
Develop, optimize and validate biochemical and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules
Work on the bench implementing state-of-the-art technologies for the different assay platforms
Ensure robust and high-quality assays with efficient use of automation and instrumentation
Data processing, interpretation and presentation to cross functional team members and
Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study
Work closely with other biology groups involved in screening, cell biology, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects
Basic understanding of molecular biology, cell biology and biochemistry techniques
Working knowledge of site-directed mutagenesis, transcriptional studies, luciferase reporter assays and qRT-PCR
Cell culture experience and in handling different immortalized cell lines, primary cell lines and 3D cultures
Ability to perform transient transfections and generate stable cell lines
Good working knowledge of immunoprecipitation and Western blotting for protein analysis and quantification
Experience in fluorescence microscopy and high-content imagining is an added advantage
Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an added advantage
Experience in CRISPR-CAS9 knock-out and siRNa/shRNA knock-down studies is an added advantage
An excellent track record of achievement is essential, reflected in peer-reviewed publications (for candidates from academic background) or in the documented delivery of scientific programmes, milestones or objectives (for candidates from industry).
A working knowledge of methods for small-molecule lead discovery is essential, but might not be essential (particularly for academic candidates).
Candidates must be capable of excellent teamwork in a fast-paced, multidisciplinary environment, where meeting timelines will be essential.
Excellent data analysis and interpretation skills
Ability to participate in project team meetings and contribute to the project(s) intellectually
Ability to overcome technical challenges and exercise sound judgment under pressure
High self-motivation to initiate projects and work independently under aggressive deadlines
An excellent personal rapport and an ability to engender trust and respect
An ability to work well as part of a small focussed team and build relationships
An exceptional communication skill and an ease in interaction with all stakeholders
An infectious enthusiasm for life, work and making a difference to the world in which we live
A bright, friendly, flexible personality with agility to switch between different skill sets
An exceptional organizational skill that thrives working in a fast-paced and vibrant team environment
Positivity, focus and a winning mentality allied with kindness
Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture