Senior Research Associate/Scientist - Cell Biology

Reporting to senior team leader, work with a group of in vitro assay biologists, learning and coaching group members to improve skills and productivity

Independently design, conduct, optimize and proactively troubleshoot assays

Develop, optimize and validate biochemical and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules

Work on the bench implementing state-of-the-art technologies for the different assay platforms

Ensure robust and high-quality assays with efficient use of automation and instrumentation

Data processing, interpretation and presentation to cross functional team members and

Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study

Work closely with other biology groups involved in screening, cell biology, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Strong experience in cell-based assay development and troubleshooting skills; ability to handle different plate formats for small molecule screening

Extensive work experience in cell biology and biochemistry techniques

Good working knowledge of transcription-based studies, targeted protein degradation, target identification and validation

Cell culture experience and in handling different immortalized cell lines, primary cultures, 3D cultures

Ability to perform transient transfections and generate stable cell lines

Good working knowledge of immunoprecipitation and Western blotting for protein analysis, quantification and in studying protein-protein interactions

Experience in fluorescence microscopy and high-content imagining is an advantage

Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an advantage

Experience in CRISPR-CAS9 knock-out and siRNA/shRNA knock-down studies

Experience with site-directed mutagenesis is beneficial but not a must

An excellent track record of achievement is essential, reflected in peer-reviewed publications (for candidates from academic background) or in the documented delivery of scientific programmes, milestones or objectives (for candidates from industry).

A working knowledge of methods for small-molecule lead discovery is essential, but might not be essential (particularly for academic candidates).

Candidates must be capable of excellent teamwork in a fast-paced, multidisciplinary environment, where meeting timelines will be essential.

Excellent data analysis and interpretation skills

An ability to overcome technical challenges and exercise sound judgment under pressure

High self-motivation to initiate projects and work independently under aggressive deadlines

A strong technical knowledge with exceptional attention to detail

An excellent personal rapport and an ability to engender trust and respect

An ability to work well as part of a small focussed team and build relationships

An exceptional communication skill and an ease in interaction with all stakeholders

An infectious enthusiasm for life, work and making a difference to the world in which we live

A bright, friendly, flexible personality with agility to switch between different skill sets

An exceptional organisational skill that thrives working in a fast-paced and vibrant team environment

Positivity, focus and a winning mentality allied with kindness

Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture