Scientist/Senior Scientist/SRA - Biology

Job description

    • Reporting to head of biology, lead a group of in vitro assay biologists, coaching group members to improve skills and productivity

    • Independently design, conduct, optimize and proactively troubleshoot screening assays

    • Develop, optimize and validate biophysical, biochemical and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules

    • Work on the bench implementing state-of-the-art technologies for the different assay platforms- managing motivating and training junior members within the group

    • Ensure robust and high-quality assays with efficient use of automation and instrumentation

    • Data processing, interpretation and presentation to cross-functional team members

    • Proposing, planning, quoting, tracking reagent needs, usage and executing timelines for each study

    • Work closely with other biology groups involved in cellular and molecular biology, protein biology/chemistry, and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Job requirements

    • Strong experience  of working with small-molecule drug discovery from a CRO/Drug Discovery company/Translational Research with an ability to efficiently handle time-bound and service-based projects

    • Should have a minimum of 5 years experience in the relevant profile.

    • Broad research experience in cell-free and cell-based assay development like using luminescence and fluorescence-based methods. E.g. FRET, TR-FRET, FP, Anisotropy, HTRF, BRET, AlphaScreen, etc. (however not limited)

    • Experience working with board target classes -e.g. enzymes, GPCRs, transporters, ion channels, surface receptors, etc. across different therapeutic areas

    • Strong experience in medium and high-throughput screening using cell-free and cell-based assays

    • Experience with binding assays - particularly hands-on experience with Surface Plasmon Resonance (SPR) or Microscale Thermophoresis (MST) will be an advantage

    • Ability to plan and design experiments, order reagents, set up assay platforms and deliver them in a timely fashion

    • Experience in the generation of stable cell lines required for cell-based assay development and screening

    • Understanding of basic molecular biology, cell biology and biochemistry experiments will be an advantage

    • Managerial experience of junior scientists

    • Excellent data analysis and interpretation skills

    • Ability to participate in project team meetings and contribute to the project(s) intellectually

    • Ability to overcome technical challenges and exercise sound judgment under pressure

    • High self-motivation to initiate projects and work independently under aggressive deadlines

    • Should have strong technical knowledge with exceptional attention to detail

    • An excellent personal rapport and an ability to engender trust and respect

    • An ability to work well as part of a small focussed team and build relationships

    • An exceptional communication skills and ease in interaction with all stakeholders

    • An infectious enthusiasm for life, work and making a difference to the world in which we live

    • A bright, friendly, flexible personality with agility to switch between different skill sets

    • An exceptional organisational skills that thrive working in a fast-paced and vibrant team environment

    • Positivity, focus, and a winning mentality allied with kindness

    • Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture.